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Sancti Spiritus, City Centre intro. The fascinating Cuban city of Sancti Spiritus is the capital of the province of the same name, located in central Cuba. Once famous as a hub for the Cuban sugar trade, it's one of the best preserved historic cities in the whole of the Caribbean. Founded in 1514, many landmarks from the period are still standing in the old city centre, including Parroquial Mayor Church, the impressive palace of the Valle Iznaga family (now the Colonial Art Museum) and the charming pedestrian-only bridge over the River Yayabu. Not yet overwhelmed by the vagaries of mass tourism, the central old part of town has charming cobblestone alleyways winding around and along the river banks, unassuming and often deserted during the day. The heart of the old city centre is its main square, Plaza Serafin Sanchez, lined with colonial architecture, and within a short walk of Sancti Spiritus City Centre hotels and the town's major landmarks and heritage sites.