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Toledo intro. Toledo is most well-known as a city in Spain. However, it also has a namesake, Toledo in Lucas County, Ohio. It is one of the largest cities in Ohio, with a population of just over 300,000. The city can often feel a little larger than this though, as the wider Lucas County area has about 650,000 inhabitants. Guests at hotels here will find several places of interest in the city and it is also the home of Toledo University. The university is highly-regarded nationally for its College of Medicine. Toledo hotels are located all over the city and visitors should be able to find an accommodation in the area they need to stay. This town is served by four interstate highways and visitors could even choose a lodge based on where they arrive in the city. Visitors interested in rare plants should visit the Metroparks. To make the most of the parks, visitors should ride the three bicycle trails in the parks.